THE JOURNAL OF ANTIBIOTICS SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 7iS-[(Z)-2-(2-AMINOTHIAZOL-4-YL)-3-(SUBSTITUTED)-2-PROPENOYL- AMINO]-3-DESACETOXYMETHYLCEPHALOSPORINS
نویسندگان
چکیده
Synthesis and biological activity of a series of 7^[(Z)-2-(2-aminothiazol-4-yl)-3-(substituted)2-propenoylamino]-3-cephem-4-carboxylic acids and their pivaloyloxymethyl esters are described. These acid compounds exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Pivaloyloxymethyl esters of selected compounds in this series were found to be well absorbed from small intestine in mice. 453
منابع مشابه
Synthesis and structure-activity relationships of 7 beta-[(Z)-2-(2- aminothiazol-4-yl)-3-(substituted)-2-propenoylamino]-3-cephems with C-3 substitutions.
Synthesis and biological activity of a series of 7 beta-[(Z)-2-(2- aminothiazol-4-yl)-3-(substituted)-2-propenoylamino]-3-cephe m-4-carboxylic acids with C-3 substitutions and their pivaloyloxymethyl esters are described. These acid compounds exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Pivaloyloxymethyl esters of selected compounds in this seri...
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